Influenza Vaccine and Reimbursement Guidelines for 2024-2025 for NC Medicaid

This bulletin applies to both NC Medicaid Direct and NC Managed Care health plans.

Vaccine strains for the 2024–25 influenza vaccines were selected by the Food and Drug Administration’s Vaccines and Related Biologic Products Advisory Committee (VRBPAC) based on WHO’s recommended Northern Hemisphere 2024–25 influenza vaccine composition. For details on the 2024-2025 influenza vaccines, visit the Centers for Disease Control (CDC) Flu Season web page. 

NC Immunization Program/Vaccines for Children (NCIP/VFC)

Under NC Immunization Program/Vaccines for Children (NCIP/VFC) guidelines, the NC Division of Public Health (DPH) Immunization Branch distributes all childhood vaccines that are recommended by the Advisory Committee on Immunization Practices (ACIP) to local health departments, Federally Qualified Health Centers (FQHC), Rural Health Clinics (RHC), hospitals and private providers.

For the 2024-2025 influenza season, NCIP/VFC influenza vaccines are available at no charge to providers for children six months through 18 years of age who are eligible for the VFC program, according to the NCIP coverage criteria. The current NCIP coverage criteria and definitions of VFC categories can be found on DPH’s Immunization Branch web page.

For providers interested in enrolling in the VFC program, information can be found on the CDC information page and the NC DPH website.   

Eligible VFC children include ALL Medicaid beneficiaries (through 18 years of age).

For VFC/NCIP vaccines administered to VFC-eligible children, providers must report only the vaccine code(s) with $0.00. Providers may bill NC Medicaid for the administration fee for Medicaid.

Providers who administer privately purchased vaccines to VFC eligible beneficiaries will NOT be reimbursed for the vaccine and cannot bill the beneficiary for that cost. Only the administration fee(s) will be reimbursed.

Providers must purchase vaccines for beneficiaries who are not VFC-eligible. For Medicaid-eligible beneficiaries aged 19 years and older, purchased vaccine and administration costs may be billed to NC Medicaid, according to the guidelines stated in Tables 2 and 3 below. To determine who is eligible for NCIP influenza and other vaccines, visit DPH’s Immunization Branch web page.

Billing/Reporting Influenza Vaccines for Medicaid Beneficiaries

The following tables indicate the vaccine codes that may be either reported (with $0.00 billed) or billed (with the usual and customary charge) for influenza vaccine, depending on the age of the beneficiaries and the formulation of the vaccine. The tables also indicate the administration codes that may be billed, depending on the age of the beneficiaries and the vaccine(s) administered to them.

Note: Specific information on billing all immunization administration codes for Health Check beneficiaries can be found in the Health Check Program Guide available at the NCTracks Provider Policies, Manuals, Guidelines and Forms web page.

If you have any questions or need assistance, please contact the Immunization Branch Help Desk at 1-877-873-6247 and press option 6.

Table 1 - Influenza Billing Codes for Medicaid Beneficiaries Less Than 19 Years of Age Who Receive VFC Influenza Vaccine

These codes are reported with $0.00.

Vaccine CPT Codes to Report

Vaccine CPT Code to ReportNDC covered by VFC ProgramCPT Code Description
90656

33332-0024-03

33332-0024-04

19515-0810-41

19515-0810-52

49281-0424-50

49281-0424-88

Influenza virus vaccine, trivalent (IIV3), split virus, preservative free, 0.5 mL dosage, for intramuscular use
90657

33332-0124-10

33332-0124-11

49281-0641-15

49281-0641-78

Influenza virus vaccine, trivalent (IIV3), split virus, 0.25 mL dosage, for intramuscular use
90658

33332-0124-10

33332-0124-11

49281-0641-15

49281-0641-78

Influenza virus vaccine, trivalent (IIV3), split virus, 0.5 mL dosage, for intramuscular use
9066066019-0311-00, 66019-0311-10Influenza virus vaccine, trivalent, live (LAIV3), for intranasal use
90661

70461-0654-03

70461-0654-04

70461-0554-10

70461-0554-11

Influenza virus vaccine (ccIIV3), derived from cell cultures, subunit, antibiotic free, for intramuscular use

*NDCs listed on Table 1 are NDCs of packs of vials as distributed by the Division of Public Health. For claims processing, providers should use the NDC listed on the actual vial used for administration as listed at the bottom of this bulletin.

Administrative CPT Codes to Bill

Administration CPT Code(s) to Bill

CPT Code Description
90471EPImmunization administration (includes percutaneous, intradermal, subcutaneous or intramuscular injections); one vaccine (single or combination vaccine/toxoid)
+90472EP (add-on code)*Immunization administration (includes percutaneous, intradermal, subcutaneous or intramuscular injections); each additional vaccine (single and combination vaccine/toxoid) (List separately in addition to code for primary procedure).
90460EPImmunization administration through 18 years via any route of administration, with counseling by physician or other qualified health care professional.
90461EP

Each additional vaccine or toxoid component administered

(List separately in addition to code for primary procedure)

90473EPImmunization administration by intranasal or oral route; 1 vaccine (single or combination vaccine/toxoid). Do not report 90473 in conjunction with 90471.

* 90472 will only be used if another vaccine is given in addition to the flu vaccine. Providers may bill more than one unit of 90472 as appropriate.

Table 2 - Influenza Billing Codes for Medicaid Beneficiaries 19 to 21 Years of Age

Use the following codes to bill Medicaid for an influenza vaccine purchased and administered to beneficiaries aged 19-21 years.

Note: The VFC/NCIP provides influenza products for recipients aged six months through 18 years only. The VFC/NCIP will NOT provide influenza vaccine for recipients 19 years and older.

Vaccine CPT Codes to Report 

Vaccine CPT Code to ReportCPT Code Description
90653Influenza vaccine, inactivated (IIV), subunit, adjuvanted, for intramuscular use
90656Influenza virus vaccine, trivalent (IIV3), split virus, preservative free, 0.5 mL dosage, for intramuscular use
90658Influenza virus vaccine, trivalent (IIV3), split virus, 0.5 mL dosage, for intramuscular use
90660Influenza virus vaccine, trivalent, live (LAIV3), for intranasal use
90661Influenza virus vaccine (ccIIV3), derived from cell cultures, subunit, antibiotic free, for intramuscular use
90662Influenza virus vaccine (IIV), split virus, preservative free, enhanced immunogenicity via increased antigen content, for intramuscular use
90673Influenza virus vaccine, trivalent (RIV3), derived from recombinant DNA, hemagglutinin (HA) protein only, preservative and antibiotic free, for intramuscular use

Administrative CPT Codes to Report

Administrative CPT Code(s) to Report

CPT Code Description

90471EPImmunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections); one vaccine (single or combination vaccine/toxoid)
+90472EP (add-on code)*Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections); each additional vaccine (single and combination vaccine/toxoid) (List separately in addition to code for primary procedure).
90473EPImmunization administration by intranasal or oral route; 1 vaccine (single or combination vaccine/toxoid). Do not report 90473 in conjunction with 90471.

* 90472 will only be used if another vaccine is given in addition to the flu vaccine. Providers may bill more than one unit of 90472 as appropriate.

Table 3 - Influenza Billing Codes for Medicaid Beneficiaries 21 Years of Age and Older

Use the following codes to bill Medicaid for influenza vaccine purchased and administered to beneficiaries 21 years of age and older.

Note: The VFC/NCIP provided influenza products for VFC-age (six months through 18 years of age) beneficiaries only. The VFC/NCIP will not provide influenza vaccine for beneficiaries 19 years and older.

Vaccine CPT Code to Report

Vaccine CPT Code to ReportCPT Code Description
90653Influenza vaccine, inactivated (IIV), subunit, adjuvanted, for intramuscular use
90656Influenza virus vaccine, trivalent (IIV3), split virus, preservative free, 0.5 mL dosage, for intramuscular use
90658Influenza virus vaccine, trivalent (IIV3), split virus, 0.5 mL dosage, for intramuscular use
90660Influenza virus vaccine, trivalent, live (LAIV3), for intranasal use
90661Influenza virus vaccine (ccIIV3), derived from cell cultures, subunit, antibiotic free, for intramuscular use
90662Influenza virus vaccine (IIV), split virus, preservative free, enhanced immunogenicity via increased antigen content, for intramuscular use
90673Influenza virus vaccine, trivalent (RIV3), derived from recombinant DNA, hemagglutinin (HA) protein only, preservative and antibiotic free, for intramuscular use

Administrative CPT Code(s) to Bill

Administrative CPT Code(s) to Bill

CPT Code Description

90471

Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections); one vaccine (single or combination vaccine/toxoid) 

 

+90472 (add-on code)*

Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections); each additional vaccine (single and combination vaccine/toxoid) (List separately in addition to code for primary procedure) 

 

90473Immunization administration by intranasal or oral route; 1 vaccine (single or combination vaccine/toxoid). Do not report 90473 in conjunction with 90471.

* 90472 will only be used if another vaccine is given in addition to the flu vaccine. Providers may bill more than one unit of 90472 as appropriate.

For beneficiaries 21 years or older receiving an influenza vaccine, an evaluation and management (E/M) code cannot be reimbursed to any provider on the same day that injection administration fee codes (e.g., 90471 or 90471 and +90472) are reimbursed, unless the provider bills an E/M code for a separately identifiable service by appending modifier 25 to the E/M code.

Immunization Billing for Medicaid from FQHCs and RHCs

For beneficiaries 0 through 20 years of age

If vaccines are provided through the NCIP/VFC, the center/clinic shall report the CPT vaccine codes (with $0.00 billed) under Physician Services NPI and may bill for the administration codes (CPT procedure codes 90471EP through 90472EP OR 90460EP). This billing is appropriate when only vaccines are provided at the visit, or if vaccines were provided in conjunction with a wellness check. If a core visit was billed, CPT vaccine codes shall be reported (with $0.00 billed) under Physician Services NPI and an administration code shall not be billed.

If purchased vaccines (non-VFC eligible) were administered, the center/clinic may bill the CPT vaccine codes (with their usual and customary charge) under the Physician Services NPI for the vaccines administered and may bill for the administration codes (with the usual and customary charge). This billing is appropriate if only vaccines were given at the visit or if vaccines were given in conjunction with a wellness check. If a core visit was billed, CPT vaccine codes shall be reported (with $0.00 billed) under the Physician Services NPI provider number and the administration codes shall not be billed. For detailed billing guidance, refer to the Health Check Program Guide available at NCTracks Provider Policies, Manuals, Guidelines and Forms web page.

For beneficiaries 21 years of age and older

When purchased vaccines are administered, CPT vaccine codes may be billed (with the usual and customary charge) and administration codes may be billed (with the usual and customary charge) under the Physician Services NPI. This is applicable when vaccine administration was the only service provided that visit. When a core visit is billed, the CPT vaccine code shall be reported (with $0.00 billed) under the Physician Services NPI and an immunization administration code may not be billed.

For influenza vaccine and administration fee rates, refer to the DHB's Physician Administered Drug Program (PADP) and Physician Services Fee Schedule.

Immunization Billing for Medicaid Beneficiaries from Immunizing Pharmacies

For beneficiaries 19 years of age and older

Effective Jan. 1, 2016, NC Medicaid will reimburse pharmacies for covered vaccines, including influenza vaccines, as permitted by G.S. 90-85.15B (see below) when administered to NC Medicaid beneficiaries 19 years of age and older by an immunizing pharmacist.

Pharmacies will be allowed to bill NC Medicaid Direct for vaccines on pharmacy claims at point of sale. Immunizing pharmacists are not required to submit vaccine administration claims on medical 837P or CMS 1500 form, but this will remain an option for immunizing pharmacists who wish to do so. Additional information can be found in the Vaccine Immunization Claims Can Be Submitted on Pharmacy Claims for NC Medicaid Direct Beneficiaries published on Nov. 28, 2022.

The Vaccine Point-of-Sale (POS) Catalogs and Rate Listings is maintained with vaccine POS and rate listing information.

For NC Medicaid Managed Care health plans, pharmacy providers should refer to communications from the beneficiaries’ plan for influenza vaccine claim submission guidance.

Table 4 - Billing Codes to be used by Pharmacist for Medicaid Beneficiaries 19 Years of Age or Older via CMS 1500 or 837P Claims

Vaccine CPT Code to ReportCPT Code Description
90653CGInfluenza vaccine, inactivated (IIV), subunit, adjuvanted, for intramuscular use
90656CGInfluenza virus vaccine, trivalent (IIV3), split virus, preservative free, 0.5 mL dosage, for intramuscular use
90658CGInfluenza virus vaccine, trivalent (IIV3), split virus, 0.5 mL dosage, for intramuscular use
90660CGInfluenza virus vaccine, trivalent, live (LAIV3), for intranasal use
90661CGInfluenza virus vaccine (ccIIV3), derived from cell cultures, subunit, antibiotic free, for intramuscular use
90662CGInfluenza virus vaccine (IIV), split virus, preservative free, enhanced immunogenicity via increased antigen content, for intramuscular use
90673CGInfluenza virus vaccine, trivalent (RIV3), derived from recombinant DNA, hemagglutinin (HA) protein only, preservative and antibiotic free, for intramuscular use

*The CG modifier must be appended to every vaccine and vaccine administration CPT code used to bill vaccines by pharmacists. The CG modifier identifies a Pharmacy Provider in NCTracks for vaccine claims billing purposes.

Billing Codes to be used by Pharmacists for N.C. Medicaid Beneficiaries 19 Years of Age and Older via CMS 1500 or 837P Claims

CPT Code(s)

CPT Code Description

90471CGImmunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections); one vaccine (single or combination vaccine/toxoid)
90472CG (add-on code)*Immunization administration (includes percutaneous, intradermal, subcutaneous, or intramuscular injections); each additional vaccine. (Separately list the add-on code(s) for each additional single vaccine and/or combination vaccine/toxoid administered, in addition to the primary procedure)
90473CGImmunization administration by intranasal or oral route; 1 vaccine (single or combination vaccine/toxoid).  Do not report 90473 in conjunction with 90471.

The CG modifier must be appended to every vaccine and vaccine administration CPT code used to bill vaccines by pharmacists. The CG modifier identifies a Pharmacy Provider in NCTracks for vaccine claims billing purposes.

*Providers may bill more than one unit of 90472 as appropriate.

Please note that NDCs are required on vaccine claims.

NDC’s Change Each Year for Influenza Vaccines

Providers are required to use appropriate NDCs that correspond to the vaccine used for administration and corresponding CPT code. Note that not all products and NDCs under their respective CPT codes will be covered.

Influenza vaccines are licensed each year with new NDCs, so it is important to report the correct code for the products you are using to avoid having claims deny with edit 00996 (Mismatched NDC) which will require the claim to be resubmitted with the correct NDC. Below are the influenza vaccine procedure (CPT) codes and corresponding NDCs that should be used for the 2024-2025 influenza season:

CPT and NDC codes for the 2024-2025 Influenza Vaccine Products*

CPT Codes

NDC codes

90653

Fluad®: 70461-0024-03, 70461-0024-04

90656

Afluria®: 33332-0024-03, 33332-0024-04

Fluarix: 58160-0884-41, 58160-0884-52

FluLaval: 19515-0810-41, 19515-0810-52

Fluzone®: 49281-0424-50, 49281-0424-88

90657

Afluria®: 33332-0124-10, 33332-0124-11

Fluzone®: 49281-0641-15, 49281-0641-78

90658

Afluria®: 33332-0124-10, 33332-0124-11

Fluzone®: 49281-0641-15, 49281-0641-78

90660

FluMist®: 66019-0311-00, 66019-0311-10

90661

Flucelvax®: 70461-0654-03, 70461-0654-04, 70461-0554-10, 70461-0554-11

90662

Fluzone® High-Dose: 49281-0124-65, 49281-0124-88

90673

Flublok®: 49281-0724-10, 49281-0724-88

*Please note that for PADP medical claims, the PADP fee schedule is updated monthly with current CPT-NDC combinations and the Vaccine Point-of-Sale (POS) Catalogs and Rate Listings webpage are updated regularly with current NDCs for pharmacy point-of-sale claims.

Contact

NCTracks Call Center, 1-800-688-6696

Health Plan Pharmacy Lines

Standard Plans

  • AmeriHealth: 1-866-885-1406
  • Healthy Blue: 1-833-434-1212
  • Carolina Complete:  1-833-992-2785
  • United Healthcare:  1-855-258-1593
  • WellCare: 1-866-799-5318, option 3

Tailored Plans

  • Alliance Health: 1-855-759-9300
  • Partners: 1-866-453-7196
  • Trillium: 1-866-245-4954
  • Vaya Health: 1-800-540-6083

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